Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community

Conjugated estrogens (CE) and Bazedoxifene (BZA) combination is used to alleviate menopause-associated symptoms in women. CE+BZA undergo first-pass-metabolism in the liver and deconjugation by gut microbiome via β-glucuronidase (GUS) enzyme inside the distal gut. To date, the impact of long-term exp...

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Udgivet i:Sci Rep
Main Authors: Chen, Karen Lee Ann, Liu, Xiaoji, Zhao, Yiru Chen, Hieronymi, Kadriye, Rossi, Gianluigi, Auvil, Loretta Sue, Welge, Michael, Bushell, Colleen, Smith, Rebecca Lee, Carlson, Kathryn E., Kim, Sung Hoon, Katzenellenbogen, John A., Miller, Michael Joseph, Madak-Erdogan, Zeynep
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970144/
https://ncbi.nlm.nih.gov/pubmed/29802368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26506-1
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