Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Myeloperoxidase Activity in Inflammatory Cells

BACKGROUND: Myeloperoxidase (MPO) generates hypochlorous acid (HOCl) during inflammation and infection. We showed that secoisolariciresinol diglucoside (SDG) scavenges radiation-induced HOCl in physiological solutions. However, the action of SDG and its synthetic version, LGM2605, on MPO-catalyzed g...

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Publicat a:Biochim Biophys Acta
Autors principals: Mishra, Om P., Popov, Anatoliy V., Pietrofesa, Ralph A., Nakamaru-Ogiso, Eiko, Andrake, Mark, Christofidou-Solomidou, Melpo
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970065/
https://ncbi.nlm.nih.gov/pubmed/29524540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2018.03.003
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