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Genetic Deletion of IL-19 Exacerbates Atherogenesis in Il19(−/−) × Ldlr(−/−) Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR
OBJECTIVE: To test the hypothesis that loss of IL-19 exacerbates atherosclerosis. APPROACH AND RESULTS: Il19(−/−) mice were crossed into Ldlr(−/−) mice. Double knockout (dKO) mice had increased plaque burden in aortic arch and root compared to Ldlr(−/−) controls after 14 weeks of high fat diet (HFD)...
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| Udgivet i: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970062/ https://ncbi.nlm.nih.gov/pubmed/29674474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.310929 |
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