Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK)

BACKGROUND: Activation of the AMP-activated protein kinase (AMPK) is an attractive approach for the treatment of type 2 diabetes. AMPK activation reduces glucose levels in animal models of type 2 diabetes by increasing glucose uptake in skeletal muscles and reducing hepatic glucose production. Furth...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Grempler, Rolf, Wolff, Michael, Simon, Eric, Schmid, Ramona, Eisele, Claudia, Rieber, Kathrin, Fischer, Elke, Mettel, Sonja, Gabrielyan, Ogsen, Delic, Denis, Luippold, Gerd, Redeman, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969744/
https://ncbi.nlm.nih.gov/pubmed/29799853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197849
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