Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner

OBJECTIVE: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of IBD. This clinical association is linked pathologically to the recruitment of mucosal T cells to the liver, via vascular adhesion protein (VAP)-1-dependent enzyme activity. Our aim was to examine the expr...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Trivedi, Palak J, Tickle, Joseph, Vesterhus, Mette Nåmdal, Eddowes, Peter J, Bruns, Tony, Vainio, Jani, Parker, Richard, Smith, David, Liaskou, Evaggelia, Thorbjørnsen, Liv Wenche, Hirschfield, Gideon M, Auvinen, Kaisa, Hubscher, Stefan G, Salmi, Marko, Adams, David H, Weston, Chris J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Hepatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969351/
https://ncbi.nlm.nih.gov/pubmed/28428344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-312354
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