Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD

BACKGROUND: In cystic fibrosis and bronchiectasis, genetic mannose binding lectin (MBL) deficiency is associated with increased exacerbations and earlier mortality; associations in COPD are less clear. Preclinical data suggest MBL interferes with phagocytosis of Haemophilus influenzae, a key COPD pa...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Dicker, Alison J, Crichton, Megan L, Cassidy, Andrew J, Brady, Gill, Hapca, Adrian, Tavendale, Roger, Einarsson, Gisli G, Furrie, Elizabeth, Elborn, J Stuart, Schembri, Stuart, Marshall, Sara E, Palmer, Colin N A, Chalmers, James D
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Chronic Obstructive Pulmonary Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969339/
https://ncbi.nlm.nih.gov/pubmed/29101284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2016-209931
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