Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NFκB pathway signaling targets in LPS/IFNγ-activated BV-2 microglia cells

Neuroinflammation and microglial activation are pathological markers of a number of central nervous system (CNS) diseases. Chronic activation of microglia induces the release of excessive amounts of reactive oxygen species (ROS) and pro-inflammatory cytokines. Additionally, chronic microglial activa...

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Veröffentlicht in:J Neuroimmunol
Hauptverfasser: Cobourne-Duval, Makini K., Taka, Equar, Mendonca, Patricia, Soliman, Karam F.A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967628/
https://ncbi.nlm.nih.gov/pubmed/29759145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2018.04.018
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