The Attenuating Effects of 1,2,3,4,6 Penta-O-Galloyl-β-D-Glucose on Pro-Inflammatory Responses of LPS/IFNγ-activated BV-2 Microglial Cells through NFƙB and MAPK Signaling Pathways

BACKGROUND: Overactivated microglial cells exhibit chronic inflammatory response and can lead to the continuous production of pro-inflammatory cytokines, perpetuating inflammation, and ultimately resulting in neuronal injury. 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose (PGG), which is a naturally occurrin...

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Bibliographic Details
Published in:J Neuroimmunol
Main Authors: Mendonca, Patricia, Taka, Equar, Bauer, David, Reams, Renee R., Soliman, Karam F. A.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245951/
https://ncbi.nlm.nih.gov/pubmed/30236786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2018.09.004
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