Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands

The bromodomain-containing protein BRD9, a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex, has emerged as an attractive therapeutic target in cancer. Despite the development of chemical probes targeting the BRD9 bromodomain, there is a limited understanding of BRD9 function beyond...

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Detaylı Bibliyografya
Yayımlandı:Angew Chem Int Ed Engl
Asıl Yazarlar: Remillard, David, Buckley, Dennis L., Paulk, Joshiawa, Brien, Gerard L., Sonnett, Matthew, Seo, Hyuk-Soo, Dastierdi, Shiva, Wühr, Martin, Dhe-Paganon, Sirano, Armstrong, Scott A., Bradner, James E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967236/
https://ncbi.nlm.nih.gov/pubmed/28418626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201611281
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