Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability

The transcription factors pancreatic and duodenal homeobox 1 (Pdx1) and onecut1 (Oc1) are coexpressed in multipotent pancreatic progenitors (MPCs), but their expression patterns diverge in hormone-expressing cells, with Oc1 expression being extinguished in the endocrine lineage and Pdx1 being mainta...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Endocrinol Metab
Main Authors: Kropp, Peter A., Dunn, Jennifer C., Carboneau, Bethany A., Stoffers, Doris A., Gannon, Maureen
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966755/
https://ncbi.nlm.nih.gov/pubmed/29351489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00260.2017
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