NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population

Approximately 10–20% of patients with primary biliary cholangitis (PBC) progress to jaundice stage regardless of treatment with ursodeoxycholic acid and bezafibrate. In this study, we performed a GWAS and a replication study to identify genetic variants associated with jaundice-stage progression in...

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Udgivet i:Sci Rep
Main Authors: Nishida, Nao, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Kojima, Kaname, Kawai, Yosuke, Ueno, Kazuko, Nakamura, Hitomi, Yamashiki, Noriyo, Tanaka, Tomohiro, Tamura, Sumito, Mori, Akira, Yagi, Shintaro, Soejima, Yuji, Yoshizumi, Tomoharu, Takatsuki, Mitsuhisa, Tanaka, Atsushi, Harada, Kenichi, Shimoda, Shinji, Komori, Atsumasa, Eguchi, Susumu, Maehara, Yoshihiko, Uemoto, Shinji, Kokudo, Norihiro, Nagasaki, Masao, Tokunaga, Katsushi, Nakamura, Minoru
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966418/
https://ncbi.nlm.nih.gov/pubmed/29795304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26369-6
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