Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis

Our recent genome-wide association study found that the NELFCD/CTSZ locus was significantly associated with progression of primary biliary cholangitis (PBC) to jaundice stage in the Japanese population. In this study, we investigated the role of cathepsin Z in the etiology and pathology of PBC. Seru...

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Publicado en:Sci Rep
Main Authors: Aiba, Yoshihiro, Harada, Kenichi, Ito, Masahiro, Suematsu, Takashi, Aishima, Shinichi, Hitomi, Yuki, Nishida, Nao, Kawashima, Minae, Takatsuki, Mitsuhisa, Eguchi, Susumu, Shimoda, Shinji, Nakamura, Hitomi, Komori, Atsumasa, Abiru, Seigo, Nagaoka, Shinya, Migita, Kiyoshi, Yatsuhashi, Hiroshi, Tokunaga, Katsushi, Nakamura, Minoru
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081405/
https://ncbi.nlm.nih.gov/pubmed/30087368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30146-w
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