Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma

Despite the improvement in locoregional control of nasopharyngeal carcinoma (NPC), distant metastasis (DM), and chemoresistance persist as major causes of mortality. This study identified a novel role for miR-449b, an overexpressed gene in a validated four-miRNA signature for NPC DM, leading to chem...

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Pubblicato in:Oncogenesis
Autori principali: Bissey, Pierre-Antoine, Law, Jacqueline H., Bruce, Jeff P., Shi, Wei, Renoult, Aline, Chua, Melvin L. K., Yip, Kenneth W., Liu, Fei-Fei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966388/
https://ncbi.nlm.nih.gov/pubmed/29795279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0050-x
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