Dasatinib reduces 5-Fu-triggered apoptosis in colon carcinoma by directly modulating Src-dependent caspase-9 phosphorylation

Preclinical data have revealed the inhibitory effect of dasatinib on colon cancer. However, a combination of dasatinib and conventional chemotherapy has failed to show any meaningful outcome in a series of clinical trials. We, therefore, wondered whether Src kinase inhibitors were suitable for treat...

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Publicat a:Cell Death Discov
Autors principals: Fu, Yang, Yang, Ge, Xue, Peipei, Guo, Luwei, Yin, Yuhan, Ye, Zhiqiang, Peng, Sanfei, Qin, Yanru, Duan, Qiuhong, Zhu, Feng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966379/
https://ncbi.nlm.nih.gov/pubmed/29844931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0062-5
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