Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Medulloblastoma (MB) is the most common malignant brain tumor in children. MYC genes are frequently amplified and correlate with poor prognosis in MB. BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription. Certain cyclin-dependent kinases (CDKs) are f...

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Udgivet i:Oncogene
Main Authors: Bolin, Sara, Borgenvik, Anna, Persson, Camilla U., Sundström, Anders, Qi, Jun, Bradner, James E., Weiss, William A., Cho, Yoon-Jae, Weishaupt, Holger, Swartling, Fredrik J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966365/
https://ncbi.nlm.nih.gov/pubmed/29511348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0135-1
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