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A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo

Trimethoprim is one of the most widely used antibiotics in the world. However, its efficacy is frequently limited by its poor water solubility and dose limiting toxicity. Prodrug strategies based on conjugation of oligosaccharides to trimethoprim have great potential for increasing the solubility of...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Wang, Xiaojian, Borges, Clarissa A., Ning, Xinghai, Rafi, Mohammad, Zhang, Jingtuo, Park, Bora, Takemiya, Kiyoko, Sterzo, Carlo Lo, Taylor, W. Robert, Riley, Lee, Murthy, Niren
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966298/
https://ncbi.nlm.nih.gov/pubmed/29660287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00177
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