A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo

Trimethoprim is one of the most widely used antibiotics in the world. However, its efficacy is frequently limited by its poor water solubility and dose limiting toxicity. Prodrug strategies based on conjugation of oligosaccharides to trimethoprim have great potential for increasing the solubility of...

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Detaylı Bibliyografya
Yayımlandı:Bioconjug Chem
Asıl Yazarlar: Wang, Xiaojian, Borges, Clarissa A., Ning, Xinghai, Rafi, Mohammad, Zhang, Jingtuo, Park, Bora, Takemiya, Kiyoko, Sterzo, Carlo Lo, Taylor, W. Robert, Riley, Lee, Murthy, Niren
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966298/
https://ncbi.nlm.nih.gov/pubmed/29660287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00177
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