Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth

The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3. This proapoptotic activity has been proposed to confer a tumor suppressor activity to this classic tyrosine ki...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Ménard, Marie, Costechareyre, Clélia, Ichim, Gabriel, Blachier, Jonathan, Neves, David, Jarrosson-Wuilleme, Loraine, Depping, Reinhard, Koster, Jan, Saintigny, Pierre, Mehlen, Patrick, Tauszig-Delamasure, Servane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965893/
https://ncbi.nlm.nih.gov/pubmed/29750782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2002912
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