The Adjuvant Bordetella Colonization Factor A Attenuates Alum-Induced Th2 Responses and Enhances Bordetella pertussis Clearance from Mouse Lungs

The reemergence of pertussis or whooping cough in several countries highlights the need for better vaccines. Acellular pertussis vaccines (aPV) contain alum as the adjuvant and elicit Th2-biased immune responses that are less effective in protecting against infection than the reactogenic whole-cell...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Jennings-Gee, Jamie, Quataert, Sally, Ganguly, Tridib, D'Agostino, Ralph, Deora, Rajendar, Dubey, Purnima
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964531/
https://ncbi.nlm.nih.gov/pubmed/29531137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00935-17
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