PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani

Leishmania donovani is a causative pathogen of potentially fatal visceral leishmaniasis (VL). Therapeutic agents are available; however, their use is limited because of high cost, serious side effects, and development of antimicrobial resistance. Protective immunity against VL depends on CD4(+) Th1...

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Publicado en:Infect Immun
Autores principales: Habib, Samar, El Andaloussi, Abdeljabar, Elmasry, Khaled, Handoussa, Aya, Azab, Manar, Elsawey, Aliaa, Al-Hendy, Ayman, Ismail, Nahed
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964517/
https://ncbi.nlm.nih.gov/pubmed/29610255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00019-18
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