Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the degeneration of upper and lower motor neurons. Defects in axonal transport have been observed pre-symptomatically in the SOD1(G93A) mouse model of ALS, and have been proposed to play a role in motor neuron degener...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Gibbs, Katherine L., Kalmar, Bernadett, Rhymes, Elena R., Fellows, Alexander D., Ahmed, Mahmood, Whiting, Paul, Davies, Ceri H., Greensmith, Linda, Schiavo, Giampietro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964181/
https://ncbi.nlm.nih.gov/pubmed/29789529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0624-8
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