Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders

Hyperinsulinemia is the earliest symptom of insulin resistance (IR), but a causal relationship between the two remains to be established. Here we show that a protein kinase D2 (PRKD2) nonsense mutation (K410X) in two rhesus monkeys with extreme hyperinsulinemia along with IR and metabolic defects by...

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Publicado no:Nat Commun
Main Authors: Xiao, Yao, Wang, Can, Chen, Jia-Yu, Lu, Fujian, Wang, Jue, Hou, Ning, Hu, Xiaomin, Zeng, Fanxin, Ma, Dongwei, Sun, Xueting, Ding, Yi, Zhang, Yan, Zheng, Wen, Liu, Yuli, Shang, Haibao, Zhu, Wenzhen, Han, Chensheng, Zhang, Yulin, Ouyang, Kunfu, Chen, Liangyi, Chen, Ju, Xiao, Rui-Ping, Li, Chuan-Yun, Zhang, Xiuqin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964083/
https://ncbi.nlm.nih.gov/pubmed/29789568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04352-z
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