Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment

In type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The histone acetyl transferase p300, involved in remodeling of chromatin structure by epigenetic mechanisms, is...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Ruiz, Lucie, Gurlo, Tatyana, Ravier, Magalie A., Wojtusciszyn, Anne, Mathieu, Julia, Brown, Matthew R., Broca, Christophe, Bertrand, Gyslaine, Butler, Peter C., Matveyenko, Aleksey V., Dalle, Stéphane, Costes, Safia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964068/
https://ncbi.nlm.nih.gov/pubmed/29789539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0603-0
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