Multivalency regulates activity in an intrinsically disordered transcription factor

The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1). Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays,...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Clark, Sarah, Myers, Janette B, King, Ashleigh, Fiala, Radovan, Novacek, Jiri, Pearce, Grant, Heierhorst, Jörg, Reichow, Steve L, Barbar, Elisar J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963919/
https://ncbi.nlm.nih.gov/pubmed/29714690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36258
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