Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition

In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles slow at the mid-blastula transition (MBT). In Drosophila melanogaster embryos, down-regulation of cyclin-dependent kinase 1 (Cdk1) activity initiates this slowing by delaying replication of heterochromatic...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Seller, Charles A., O’Farrell, Patrick H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963817/
https://ncbi.nlm.nih.gov/pubmed/29746464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005687
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