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Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition

In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles slow at the mid-blastula transition (MBT). In Drosophila melanogaster embryos, down-regulation of cyclin-dependent kinase 1 (Cdk1) activity initiates this slowing by delaying replication of heterochromatic...

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Detalles Bibliográficos
Publicado en:PLoS Biol
Main Authors: Seller, Charles A., O’Farrell, Patrick H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963817/
https://ncbi.nlm.nih.gov/pubmed/29746464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005687
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