mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms

Transgenic mouse models are indispensable tools to mimic human diseases and analyze the effectiveness of related new drugs. For a long time amyotrophic lateral sclerosis (ALS) research depended on only a few mouse models that exhibit a very strong and early phenotype, e.g. SOD1 mice, resulting in a...

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Publicado en:PLoS One
Main Authors: Scherz, Barbara, Rabl, Roland, Flunkert, Stefanie, Rohler, Siegfried, Neddens, Joerg, Taub, Nicole, Temmel, Magdalena, Panzenboeck, Ute, Niederkofler, Vera, Zimmermann, Robert, Hutter-Paier, Birgit
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963763/
https://ncbi.nlm.nih.gov/pubmed/29787578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197674
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