Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR (BmDHFR) at nanomolar concentrations. These data...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Tobias, Andrew M., Toska, Dea, Lange, Keith, Eck, Tyler, Bhat, Rohit, Janson, Cheryl A., Rotella, David P., Gubler, Ueli, Goodey, Nina M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963757/
https://ncbi.nlm.nih.gov/pubmed/29787565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197173
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