Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR (BmDHFR) at nanomolar concentrations. These data...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tobias, Andrew M., Toska, Dea, Lange, Keith, Eck, Tyler, Bhat, Rohit, Janson, Cheryl A., Rotella, David P., Gubler, Ueli, Goodey, Nina M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963757/
https://ncbi.nlm.nih.gov/pubmed/29787565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197173
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