Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria

Compounds based on the 2,3-distyrylindole scaffold were found to exhibit bactericidal properties upon irradiation with white light. At the concentration of 1 μM, the lead compound 1 completely (ca. 10(9) CFU/mL) eradicated such Gram-positive organisms as S. aureus (MRSA, MSSA), E. faecalis (VRE), S....

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Edwards, Leslie, Turner, Danielle, Champion, Cody, Khandelwal, Megha, Zingler, Kailee, Stone, Cassidy, Rajapaksha, Ruwini D., Yang, Jing, Ranasinghe, Mahinda I., Kornienko, Alexander, Frolova, Liliya, Rogelj, Snezna
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963728/
https://ncbi.nlm.nih.gov/pubmed/29673980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.04.001
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