Deletion of the Insulin Receptor in Sensory Neurons Increases Pancreatic Insulin Levels

Insulin is known to have neurotrophic properties and loss of insulin support to sensory neurons may contribute to peripheral diabetic neuropathy (PDN). Here, genetically-modified mice were generated in which peripheral sensory neurons lacked the insulin receptor (SNIRKO mice) to determine whether di...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Grote, Caleb W., Wilson, Natalie M., Katz, Natalie K, Guilford, Brianne L., Ryals, Janelle M., Novikova, Lesya, Stehno-Bittel, Lisa, Wright, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963702/
https://ncbi.nlm.nih.gov/pubmed/29649429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.04.002
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