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Identification of a Small Molecule Activator for AphB, a LysR-Type Virulence Transcriptional Regulator in Vibrio cholerae

AphB is a LysR-type transcriptional regulator (LTTR) that cooperates with a second transcriptional activator, AphA, at the tcpPH promoter to initiate expression of the virulence cascade in Vibrio cholerae. Since it is not yet known whether AphB responds to a natural ligand in V. cholerae that influe...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Privett, Britney R., Pellegrini, Maria, Kovacikova, Gabriela, Taylor, Ronald K., Skorupski, Karen, Mierke, Dale, Jon Kull, F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963692/
https://ncbi.nlm.nih.gov/pubmed/28640592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00337
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