The crystal structure of AphB, a virulence gene activator from Vibrio cholerae, reveals residues that influence its response to oxygen and pH

Expression of the two critical virulence factors of Vibrio cholerae, toxin-coregulated pilus and cholera toxin, is initiated at the tcpPH promoter by the regulators AphA and AphB. AphA is a winged helix DNA-binding protein that enhances the ability of AphB, a LysR-type transcriptional regulator, to...

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Bibliographic Details
Main Authors: Taylor, Jennifer L., De Silva, Rukman S., Kovacikova, Gabriela, Lin, Wei, Taylor, Ronald K., Skorupski, Karen, Kull, F. Jon
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262181/
https://ncbi.nlm.nih.gov/pubmed/22053934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2011.07919.x
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