Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum

Zolvix(®) is a recently introduced anthelmintic drench containing monepantel as the active ingredient. Monepantel is a positive allosteric modulator of DEG-3/DES-2 type nicotinic acetylcholine receptors (nAChRs) in several nematode species. The drug has been reported to produce hypercontraction of C...

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Veröffentlicht in:Int J Parasitol Drugs Drug Resist
Hauptverfasser: Abongwa, Melanie, Marjanovic, Djordje S., Tipton, James G., Zheng, Fudan, Martin, Richard J., Trailovic, Sasa M., Robertson, Alan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963102/
https://ncbi.nlm.nih.gov/pubmed/29366967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2017.12.001
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