Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2)

Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. A high-throughput screen of ~17,000 compounds using a mobility shift assay identified two potent series of inhibitors having a pyrrolopyrimidine or pyrimidine core. The pyrrolopyrimidine 10 (I...

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Publicat a:ChemMedChem
Autors principals: Hawkinson, Jon E., Sinville, Rondedrick, Mudaliar, Deepti, Shetty, Jagathpala, Ward, Timothy, Herr, John C., Georg, Gunda I.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962959/
https://ncbi.nlm.nih.gov/pubmed/28952188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700503
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