Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations

When a small molecule binds to the androgen receptor (AR), a conformational change can occur which impacts subsequent binding of co-regulator proteins and DNA. In order to accurately study this mechanism, the scientific community needs a crystal structure of the Wild type AR (WT-AR) ligand binding d...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Sakkiah, Sugunadevi, Kusko, Rebecca, Pan, Bohu, Guo, Wenjing, Ge, Weigong, Tong, Weida, Hong, Huixiao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962723/
https://ncbi.nlm.nih.gov/pubmed/29867496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00492
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