Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies

Polyglutamine (polyQ) diseases are hereditary neurodegenerative disorders caused by an abnormal expansion of a trinucleotide CAG repeat in the coding region of their respective associated genes. PolyQ diseases mainly display progressive degeneration of the brain and spinal cord. Nine polyQ diseases...

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I publikationen:Front Mol Neurosci
Huvudupphovsmän: Xiang, Chunchen, Zhang, Shun, Dong, Xiaoyu, Ma, Shuang, Cong, Shuyan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962650/
https://ncbi.nlm.nih.gov/pubmed/29867345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00153
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