Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Drug-induced liver injury remains a concern during drug treatment and development. There is an urgent need for improved mechanistic understanding and prediction of DILI liabilities using in vitro approaches. We have established and characterized a panel of liver cell models containing mechanism-base...

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Udgivet i:Arch Toxicol
Main Authors: Wink, Steven, Hiemstra, Steven W., Huppelschoten, Suzanne, Klip, Janna E., van de Water, Bob
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
Fag:
In Vitro Systems
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962642/
https://ncbi.nlm.nih.gov/pubmed/29502165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2178-z
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