Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures...

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Bibliographic Details
Published in:Arch Toxicol
Main Authors: Proctor, William R., Foster, Alison J., Vogt, Jennifer, Summers, Claire, Middleton, Brian, Pilling, Mark A., Shienson, Daniel, Kijanska, Monika, Ströbel, Simon, Kelm, Jens M., Morgan, Paul, Messner, Simon, Williams, Dominic
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
Subjects:
In Vitro Systems
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515971/
https://ncbi.nlm.nih.gov/pubmed/28612260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2002-1
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