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All-Atom Simulations Reveal How Single-Point Mutations Promote Serpin Misfolding
Protein misfolding is implicated in many diseases, including serpinopathies. For the canonical inhibitory serpin α(1)-antitrypsin, mutations can result in protein deficiencies leading to lung disease, and misfolded mutants can accumulate in hepatocytes, leading to liver disease. Using all-atom simul...
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| Izdano u: | Biophys J |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Biophysical Society
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5961751/ https://ncbi.nlm.nih.gov/pubmed/29742402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.03.027 |
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