In cell mutational interference mapping experiment (in cell MIME) identifies the 5′ polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging

Non-coding RNA regulatory elements are important for viral replication, making them promising targets for therapeutic intervention. However, regulatory RNA is challenging to detect and characterise using classical structure-function assays. Here, we present in cell Mutational Interference Mapping Ex...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Smyth, Redmond P, Smith, Maureen R, Jousset, Anne-Caroline, Despons, Laurence, Laumond, Géraldine, Decoville, Thomas, Cattenoz, Pierre, Moog, Christiane, Jossinet, Fabrice, Mougel, Marylène, Paillart, Jean-Christophe, von Kleist, Max, Marquet, Roland
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961354/
https://ncbi.nlm.nih.gov/pubmed/29514260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky152
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