Surface-exposed loops and an acidic patch in the Scl1 protein of group A Streptococcus enable Scl1 binding to wound-associated fibronectin

Keratinized epidermis constitutes a powerful barrier of the mucosa and skin, effectively preventing bacterial invasion, unless it is wounded and no longer protective. Wound healing involves deposition of distinct extracellular matrix (ECM) proteins enriched in cellular fibronectin (cFn) isoforms con...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: McNitt, Dudley H., Choi, Soo Jeon, Keene, Douglas R., Van De Water, Livingston, Squeglia, Flavia, Berisio, Rita, Lukomski, Slawomir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961034/
https://ncbi.nlm.nih.gov/pubmed/29615492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002250
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