Simplified qPCR method for detecting excessive mtDNA damage induced by exogenous factors

Damage to mitochondrial DNA (mtDNA) is a meaningful biomarker for evaluating genotoxicity of drugs and environmental toxins. Existing PCR methods utilize long mtDNA fragments (~8–10 kb), which complicates detecting exact sites of mtDNA damage. To identify the mtDNA regions most susceptible to damage...

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Publicat a:Toxicology
Autors principals: Gureev, Artem P., Shaforostova, Ekaterina A., Starkov, Anatoly A., Popov, Vasily N.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960598/
https://ncbi.nlm.nih.gov/pubmed/28286206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2017.03.010
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