Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells

Formation of the androgen receptor splicing variant 7 (AR-V7) is one of the major mechanisms by which resistance of prostate cancer to androgen deprivation therapy occurs. The histone demethylase JMJD1A (Jumonji domain containing 1A) functions as a key coactivator for AR by epigenetic regulation of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fan, Lingling, Zhang, Fengbo, Xu, Songhui, Cui, Xiaolu, Hussain, Arif, Fazli, Ladan, Gleave, Martin, Dong, Xuesen, Qi, Jianfei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960326/
https://ncbi.nlm.nih.gov/pubmed/29712835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802415115
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