MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly un...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Skucha, Anna, Ebner, Jessica, Schmöllerl, Johannes, Roth, Mareike, Eder, Thomas, César-Razquin, Adrián, Stukalov, Alexey, Vittori, Sarah, Muhar, Matthias, Lu, Bin, Aichinger, Martin, Jude, Julian, Müller, André C., Győrffy, Balázs, Vakoc, Christopher R., Valent, Peter, Bennett, Keiryn L., Zuber, Johannes, Superti-Furga, Giulio, Grebien, Florian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959866/
https://ncbi.nlm.nih.gov/pubmed/29777171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04329-y
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