HIV latency in isolated patient CD4(+) T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

Latently infected CD4(+) T cells are the main barrier to complete clearance of HIV infection, but it is unclear what mechanisms govern latent HIV infection in vivo. To address this question, we developed a new panel of reverse transcription droplet digital polymerase chain reaction (RT-ddPCR) assays...

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Bibliographic Details
Published in:Sci Transl Med
Main Authors: Yukl, Steven A., Kaiser, Philipp, Kim, Peggy, Telwatte, Sushama, Joshi, Sunil K., Vu, Mai, Lampiris, Harry, Wong, Joseph K.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959841/
https://ncbi.nlm.nih.gov/pubmed/29491188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aap9927
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