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Disease-causing mutations in the G protein Gαs subvert the roles of GDP and GTP
The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that th...
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| izdano v: | Cell |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5959768/ https://ncbi.nlm.nih.gov/pubmed/29628140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.018 |
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