Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers

WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling on autophagy in glioblastoma (GBM), a devastating brain tumor. Inhibiting TC...

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Publicat a:Autophagy
Autors principals: Nàger, Mireia, Sallán, Marta C., Visa, Anna, Pushparaj, Charumathi, Santacana, Maria, Macià, Anna, Yeramian, Andrée, Cantí, Carles, Herreros, Judit
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Papers - Basic Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959333/
https://ncbi.nlm.nih.gov/pubmed/29313411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1423439
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