Effects of Cytochrome P450 (CYP) 2C19 Genotypes on Steady-State Plasma Concentrations of Escitalopram and its Desmethyl Metabolite in Japanese Patients With Depression

BACKGROUND: Plasma concentrations of the S-enantiomer of citalopram were different between extensive and poor CYP2C19 metabolizers in healthy subjects and depressed patients. However, most studies applied dose-corrected concentrations. Thus, we studied the effects of polymorphisms of the CYP2C19 gen...

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Publicat a:Ther Drug Monit
Autors principals: Tsuchimine, Shoko, Ochi, Shinichiro, Tajiri, Misuzu, Suzuki, Yutaro, Sugawara, Norio, Inoue, Yoshimasa, Yasui-Furukori, Norio
Format: Artigo
Idioma:Inglês
Publicat: Therapeutic Drug Monitoring 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959260/
https://ncbi.nlm.nih.gov/pubmed/29570504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000506
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