Characterization of Postinfusion Phenotypic Differences in Fresh Versus Cryopreserved TCR Engineered Adoptive Cell Therapy Products

Adoptive cell therapy (ACT) consisting of genetically engineered T cells expressing tumor antigen-specific T-cell receptors displays robust initial antitumor activity, followed by loss of T-cell activity/persistence and frequent disease relapse. We characterized baseline and longitudinal T-cell phen...

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Detalles Bibliográficos
Publicado en:J Immunother
Autores principales: Nowicki, Theodore S., Escuin-Ordinas, Helena, Avramis, Earl, Chmielowski, Bartosz, Chodon, Thinle, Berent-Maoz, Beata, Wang, Xiaoyan, Kaplan-Lefko, Paula, Yang, Lili, Baltimore, David, Economou, James S., Ribas, Antoni, Comin-Anduix, Begoña
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Clinical Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959255/
https://ncbi.nlm.nih.gov/pubmed/29470191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000216
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